No Serological Indications That Sjögren’s Syndrome Is Linked with Human Parvovirus B19 Infection
Kaddachi Imene, Regaya Faouzi
Background: The association of Human parvovirus B19 infection with autoimmune disorders has been well documented. Some recent studies have suggested a possible role of B19 in the Sjögren’s syndrome pathogenesis.
Objectives: To investigate the prevalence of anti-B19 IgM and IgG antibodies and to detect viral DNA in serum samples of patients with Sjögren’s syndrome.
Methods: We assessed antibodies against Parvovirus B19 in serum samples from two patients with Sjögren’s syndrome and from healthy volunteers. Blood samples were examined for B19 serology and genome expression.
Results: Positivity for IgM and IgG antibodies to B19 was not detected in any patients. None of these patients showed evidence for B19 viremia.
Conclusions: This study showed that none of the patients with Sjögren’s syndrome showed serological markers of Human Parvovirus B19 infection. Therefore, we don’t support an association between Sjögren’s syndrome and B19 infection.
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