International Journal of Applied Science and Technology

ISSN 2221-0997 (Print), 2221-1004 (Online) 10.30845/ijast

Some Amino Acid Derivatives Containing Selenium Part (II): Anticancer Activity and of Their Cu (II)-Complexes
Dhafir M. Husain Al-Mudhaffar

Anticancer activity of two amino acid derivatives containing selenium [3,5 dinitrobenzoylamino- selenomethyl] Amino Acid; where amino acids; glycine; DNBASG (1) and alanine DNBASA (2) have been done. Anticancer properties against breast cancer (MCF-7) and carcinoma of the uterine cervix (HeLa) were accomplished for compounds (1) and (2) and show lower cytotoxic activity as compared to the antitumor agents 5-fluorouracil, cyclophosphamid and cisplatin. Cupric complexes of the two derivatives (I) and (2) were prepared but lack of solubility prevented the anticancer activity test to be done for them.

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