International Journal of Applied Science and Technology

ISSN 2221-0997 (Print), 2221-1004 (Online) 10.30845/ijast

Synthesis, Characterization and Evaluation of Biological Activity of New Heterocyclic Compounds Containing 1,2,4- Triazoleand 1,3,4-Thiadiazole Rings
Mustafa M. Abdulrasool, Alaa H. Jawad, Jawad K. Shneine

In this study, a new Triazole derivative was synthesized by many cyclization reactions. Compound (1) was cyclized by the reaction of hydrazine hydrate with carbon disulfide. The compound (1) was reacted with chloroethyl acetate in presence of alkali ethanol to give the ester (2). The compound (3) was obtained from the reaction of compound (2) with hydrazine hydrate. The salt (4) was formation by reacting of compound (3) with CS2inalkali ethanol. The cyclization of salt (4) with hydrazine hydrate was involved formation of compound (5). The last step of this study was prepared the derivative (6) by the cyclization reaction of compound (5) with p-Bromophenacyl bromide. The biological evaluated of compound (5) and (6) were studied. The result showed that the compounds (5) and (6) possess high biological activity.

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