International Journal of Applied Science and Technology

ISSN 2221-0997 (Print), 2221-1004 (Online) 10.30845/ijast

Modeling of ibuprofen on reversed phase liquid chromatography: I. The effect of mobile phase composition
Tarab Ahmad, Bobilla Srihari, Bakheet Alresheedi, Siddegowda Chandraju, Netkal Made Gowda

Abstract
The present work investigates the modeling of ibuprofen on reversed phase liquid chromatography using a mobile phase containing aqueous solution of acetonitrile at pH 2.2. The adsorption isotherms of ibuprofen are determined by frontal analysis method and by the inverse method. It was found that the adsorption data fit the S-shaped model. All the parameters of the isotherm decrease by increasing the amount of acetonitrile in the mobile phase. There was a good agreement between the experimental and the calculated band profiles.

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